Mesangial cell proliferation,extracellular matrix(ECM) and collagen deposition were suppressed by GTW. Expressions of α-SMA and collagen type Ⅰ decreased,and the characteristic changes of GS were attenuated.
GTW抑制模型鼠系膜细胞增殖、细胞外基质(ECM)和胶原沉积,减少α-SMA、I型胶原表达,改善GS特征性病变。
参考来源 - 雷公藤多苷对阿霉素肾病模型鼠肾组织TGF. Glomerular extracellular matrix (ECM) accumulation and base-membrane thickness and glomerular mesangial cell proliferation is decreased after treatment of TZDs.
经TZD治疗后糖尿病肾小球内细胞外基质蓄积、基底膜增厚及肾小球系膜细胞增生减轻 。
参考来源 - TZD对糖尿病大鼠肾脏保护作用及机制的研究·2,447,543篇论文数据，部分数据来源于NoteExpress
Objective To examine the influence of antisense MCP-1 on MCP-1 production and mesangial cell proliferation.
目的研究反义单核细胞趋化蛋白1 (MCP - 1)对系膜细胞MCP - 1分泌及增生的影响。
Aim to evaluate the effects of aldosterone (ald) and spironolactone (spi, one of the aldosterone receptor antagonists) on proliferation and cell cycle phase of cultured rat mesangial cells in vitro.
目的研究醛固酮(ald)及其受体拮抗剂螺内酯(SPI)对大鼠肾小球系膜细胞增殖和细胞周期的影响。
Conclusion ALD inhibits the proliferation of rat mesangial cells by regulating cell cycle.
结论ALD通过调控细胞周期抑制肾小球系膜细胞增殖。
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